A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

A coding mutation in the human insulin gene (His-B10----Asp) is associated with familial hyperproinsulinemia. To model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of Langerhans. Strain 24-6 mice, containing about 100 copies of the...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Carroll, R J, Hammer, R E, Chan, S J, Swift, H H, Rubenstein, A H, Steiner, D F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3057496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.8943
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