A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.
A coding mutation in the human insulin gene (His-B10----Asp) is associated with familial hyperproinsulinemia. To model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of Langerhans. Strain 24-6 mice, containing about 100 copies of the...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3057496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.23.8943 |
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