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Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase
Nitroheterocyclic prodrugs have been used to treat trypanosomal diseases for more than 40 years. Recently, the key step involved in the activation of these compounds has been elucidated and shown to be catalyzed by a type I nitroreductase (NTR). This class of enzyme is normally associated with bacte...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825977/ https://ncbi.nlm.nih.gov/pubmed/20028822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01213-09 |
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