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Effects of Geometric Isomerism and Anions on the Kinetics and Mechanism of the Stepwise Formation of Long-Range DNA Interstrand Cross-Links by Dinuclear Platinum Antitumor Complexes
Reported herein is a detailed study of the kinetics and mechanism of formation of a 1,4-GG interstrand cross-link by the dinuclear platinum anticancer compound [(15)N][{cis-PtCl-(NH(3))(2)}(2){μ-NH(2)(CH(2))(6)NH(2)}](2+) (1,1/c,c (1)). The reaction of [(15)N]1 with 5′-{d(ATATGTACATAT)(2)} (I) has b...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825901/ https://ncbi.nlm.nih.gov/pubmed/18537208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200800408 |
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