BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer

In sporadic epithelial ovarian cancer (EOC), the inactivation of BRCA1 through various mechanisms is a relatively common event. BRCA1 protein dysfunction results in the breakdown of various critical pathways in the cell, notably, the DNA damage response and repair pathway. Tumors from patients with...

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Detaylı Bibliyografya
Asıl Yazarlar: Clark-Knowles, Katherine V., O'Brien, Anna M., Weberpals, Johanne I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi Publishing Corporation 2010
Konular:
Review Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825770/
https://ncbi.nlm.nih.gov/pubmed/20182637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/891059
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