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Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

Viruses rely on the metabolic network of their cellular hosts to provide energy and building blocks for viral replication. We developed a flux measurement approach based on liquid chromatography–tandem mass spectrometry to quantify changes in metabolic activity induced by human cytomegalovirus (HCMV...

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Detalhes bibliográficos
Main Authors: Munger, Joshua, Bennett, Bryson D, Parikh, Anuraag, Feng, Xiao-Jiang, McArdle, Jessica, Rabitz, Herschel A, Shenk, Thomas, Rabinowitz, Joshua D
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825756/
https://ncbi.nlm.nih.gov/pubmed/18820684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1500
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