Intraneuronal Amyloid β Accumulation and Oxidative Damage to Nucleic Acids in Alzheimer Disease

An in situ approach was used to identify amyloid-β (Aβ) accumulation and oxidative damage to nucleic acids in postmortem brain tissue of the hippocampal formation from subjects with Alzheimer disease. When carboxyl-terminal specific antibodies directed against Aβ40 and Aβ42 were used for immunocytoc...

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Hauptverfasser: Nunomura, Akihiko, Tamaoki, Toshio, Tanaka, Koich, Motohashi, Nobutaka, Nakamura, Masao, Hayashi, Takaaki, Yamaguchi, Haruyasu, Shimohama, Shun, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A., Perry, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825655/
https://ncbi.nlm.nih.gov/pubmed/20034567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.12.012
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