Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

Bax and Bid are pro-apoptotic members of the Bcl-2 protein family. Upon cleavage by caspase-8, Bid activates Bax. Activated Bax inserts into the mitochondrial outer membrane forming oligomers which lead to membrane poration, release of cytochrome c, and apoptosis. The detailed mechanism of Bax activ...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Bleicken, Stephanie, Classen, Mirjam, Padmavathi, Pulagam V. L., Ishikawa, Takashi, Zeth, Kornelius, Steinhoff, Heinz-Jürgen, Bordignon, Enrica
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825459/
https://ncbi.nlm.nih.gov/pubmed/20008353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081539
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker