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Defects in 18 S or 28 S rRNA Processing Activate the p53 Pathway
The p53 tumor suppressor pathway is activated by defective ribosome synthesis. Ribosomal proteins are released from the nucleolus and block human double minute-2 (Hdm2) that targets p53 for degradation. However, it remained elusive how abrogation of individual rRNA processing pathways contributes to...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825431/ https://ncbi.nlm.nih.gov/pubmed/20056613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054734 |
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