Inhibition of ERK1/2 and Activation of Liver X Receptor Synergistically Induce Macrophage ABCA1 Expression and Cholesterol Efflux

ATP-binding cassette transporter A1 (ABCA1), a molecule mediating free cholesterol efflux from peripheral tissues to apoAI and high density lipoprotein (HDL), inhibits the formation of lipid-laden macrophage/foam cells and the development of atherosclerosis. ERK1/2 are important signaling molecules...

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Autors principals: Zhou, Xiaoye, Yin, Zhinan, Guo, Xianzhi, Hajjar, David P., Han, Jihong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Lipids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825427/
https://ncbi.nlm.nih.gov/pubmed/20037141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073601
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