Tyrosine-Phosphorylation-Dependent Translocation of the SLAT Protein to the Immunological Synapse Is Required for NFAT Transcription Factor Activation

SWAP-70-like adaptor of T cells (SLAT) is a guanine nucleotide exchange factor for Rho GTPases that regulates the development of T helper 1 (Th1) and Th2 cell inflammatory responses by controlling the Ca(2+)-NFAT signaling pathway. However, the mechanism used by SLAT to regulate these events is unkn...

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Hlavní autoři: Bécart, Stéphane, Canonigo Balancio, Ann J., Charvet, Céline, Feau, Sonia, Sedwick, Caitlin E., Altman, Amnon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825161/
https://ncbi.nlm.nih.gov/pubmed/18976935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.08.015
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