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SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca(2+)/NFAT signaling
SWAP-70–like adapter of T cells (SLAT) is a novel guanine nucleotide exchange factor for Rho GTPases that is upregulated in Th2 cells, but whose physiological function is unclear. We show that SLAT(–/–) mice displayed a developmental defect at one of the earliest stages of thymocyte differentiation,...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2007
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1924495/ https://ncbi.nlm.nih.gov/pubmed/17657315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31640 |
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