SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca(2+)/NFAT signaling

SWAP-70–like adapter of T cells (SLAT) is a novel guanine nucleotide exchange factor for Rho GTPases that is upregulated in Th2 cells, but whose physiological function is unclear. We show that SLAT(–/–) mice displayed a developmental defect at one of the earliest stages of thymocyte differentiation,...

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Autors principals: Bécart, Stéphane, Charvet, Céline, Canonigo Balancio, Ann J., De Trez, Carl, Tanaka, Yoshihiko, Duan, Wei, Ware, Carl, Croft, Michael, Altman, Amnon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924495/
https://ncbi.nlm.nih.gov/pubmed/17657315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31640
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