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Ubiquitin docking at the proteasome via a novel PH domain interaction
Targeted protein degradation is largely performed by the ubiquitin-proteasome pathway, in which substrate proteins are marked by covalently attached ubiquitin chains that mediate recognition by the proteasome. It is currently unclear how the proteasome recognizes its substrates, as the only establis...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825158/ https://ncbi.nlm.nih.gov/pubmed/18497827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06924 |
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