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Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia
Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824913/ https://ncbi.nlm.nih.gov/pubmed/20107070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5150-09.2010 |
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