Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia

Transient receptor potential vanilloid-1 (TRPV1) antagonists are widely viewed as next-generation pain therapeutics. However, these compounds cause hyperthermia, a serious side effect. TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g...

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Main Authors: Garami, Andras, Shimansky, Yury P., Pakai, Eszter, Oliveira, Daniela L., Gavva, Narender R., Romanovsky, Andrej A.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2010
主題:
Brief Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824913/
https://ncbi.nlm.nih.gov/pubmed/20107070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5150-09.2010
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