TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis via increased aerobic glycolysis and HIF1α stabilization

PURPOSE: This study aims to investigate the role of aberrant expression of TKTL1 (Transkelolase-like 1) in Head and Neck Squamous Cell Carcinoma (HNSCC) tumorigenesis and to characterize TKTL1 contribution to HNSCC tumorigenesis via aerobic glycolysis and HIF1α stabilization. EXPERIMENTAL DESIGN: TK...

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Detalhes bibliográficos
Main Authors: Sun, Wenyue, Liu, Yan, Glazer, Chad A., Shao, Chunbo, Bhan, Sheetal, Demokan, Semra, Zhao, Ming, Rudek, Michelle A., Ha, Patrick K., Califano, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824550/
https://ncbi.nlm.nih.gov/pubmed/20103683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2604
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