Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

Large-scale protein signalling networks are useful for exploring complex biochemical pathways but do not reveal how pathways respond to specific stimuli. Such specificity is critical for understanding disease and designing drugs. Here we describe a computational approach—implemented in the free CNO...

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Hauptverfasser: Saez-Rodriguez, Julio, Alexopoulos, Leonidas G, Epperlein, Jonathan, Samaga, Regina, Lauffenburger, Douglas A, Klamt, Steffen, Sorger, Peter K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824489/
https://ncbi.nlm.nih.gov/pubmed/19953085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2009.87
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