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Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

Large-scale protein signalling networks are useful for exploring complex biochemical pathways but do not reveal how pathways respond to specific stimuli. Such specificity is critical for understanding disease and designing drugs. Here we describe a computational approach—implemented in the free CNO...

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Sonraí Bibleagrafaíochta
Main Authors: Saez-Rodriguez, Julio, Alexopoulos, Leonidas G, Epperlein, Jonathan, Samaga, Regina, Lauffenburger, Douglas A, Klamt, Steffen, Sorger, Peter K
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824489/
https://ncbi.nlm.nih.gov/pubmed/19953085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2009.87
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