Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close relatives: Nedd4 (...

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Hlavní autoři: Persaud, Avinash, Alberts, Philipp, Amsen, Eva M, Xiong, Xuejian, Wasmuth, James, Saadon, Zachary, Fladd, Chris, Parkinson, John, Rotin, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824488/
https://ncbi.nlm.nih.gov/pubmed/19953087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2009.85
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