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Regulation of lipid droplet turnover by ubiquitin ligases

Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ub...

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Hlavní autoři: Alberts, Philipp, Rotin, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906420/
https://ncbi.nlm.nih.gov/pubmed/20646264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-8-94
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