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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

The broadly neutralizing anti-HIV antibody 4E10 recognizes an epitope very close to the virus membrane on the glycoprotein gp41. It was previously shown that epitope recognition improves in a membrane context and that 4E10 binds directly, albeit weakly, to lipids. Furthermore, a crystal structure of...

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Bibliografske podrobnosti
Main Authors: Scherer, Erin M., Leaman, Daniel P., Zwick, Michael B., McMichael, Andrew J., Burton, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824387/
https://ncbi.nlm.nih.gov/pubmed/20080706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909680107
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