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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions
The broadly neutralizing anti-HIV antibody 4E10 recognizes an epitope very close to the virus membrane on the glycoprotein gp41. It was previously shown that epitope recognition improves in a membrane context and that 4E10 binds directly, albeit weakly, to lipids. Furthermore, a crystal structure of...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824387/ https://ncbi.nlm.nih.gov/pubmed/20080706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909680107 |
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