Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

The viral spike of HIV-1 is composed of three gp120 envelope glycoproteins attached noncovalently to three gp41 transmembrane molecules. Viral entry is initiated by binding to the CD4 receptor on the cell surface, which induces large conformational changes in gp120. These changes not only provide a...

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Main Authors: Pancera, Marie, Majeed, Shahzad, Ban, Yih-En Andrew, Chen, Lei, Huang, Chih-chin, Kong, Leopold, Kwon, Young Do, Stuckey, Jonathan, Zhou, Tongqing, Robinson, James E., Schief, William R., Sodroski, Joseph, Wyatt, Richard, Kwong, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824281/
https://ncbi.nlm.nih.gov/pubmed/20080564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911004107
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