Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the conse...

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Main Authors: Dumortier, Alexis, Durham, André-Dante, Di Piazza, Matteo, Vauclair, Sophie, Koch, Ute, Ferrand, Gisèle, Ferrero, Isabel, Demehri, Shadmehr, Song, Lynda Li, Farr, Andrew G., Leonard, Warren J., Kopan, Raphael, Miele, Lucio, Hohl, Daniel, Finke, Daniela, Radtke, Freddy
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823782/
https://ncbi.nlm.nih.gov/pubmed/20174635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009258
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