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Mechanism of Substrate Recognition and Insight into Feedback Inhibition of Homocitrate Synthase from Thermus thermophilus
Homocitrate synthase (HCS) catalyzes aldol-type condensation of acetyl coenzyme A (acetyl-CoA) and α-ketoglutarate (α-KG) to synthesize homocitrate (HC), which is the first and committed step in the lysine biosynthetic pathway through α-aminoadipate. As known in most enzymes catalyzing the first rea...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823558/ https://ncbi.nlm.nih.gov/pubmed/19996101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086330 |
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