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Mechanism of Substrate Recognition and Insight into Feedback Inhibition of Homocitrate Synthase from Thermus thermophilus

Homocitrate synthase (HCS) catalyzes aldol-type condensation of acetyl coenzyme A (acetyl-CoA) and α-ketoglutarate (α-KG) to synthesize homocitrate (HC), which is the first and committed step in the lysine biosynthetic pathway through α-aminoadipate. As known in most enzymes catalyzing the first rea...

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Autori principali: Okada, Takuya, Tomita, Takeo, Wulandari, Asri P., Kuzuyama, Tomohisa, Nishiyama, Makoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823558/
https://ncbi.nlm.nih.gov/pubmed/19996101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086330
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