IKKϵ Phosphorylation of Estrogen Receptor α Ser-167 and Contribution to Tamoxifen Resistance in Breast Cancer

IKKϵ has recently been identified as a breast cancer oncogene. Elevated levels of IKKϵ are associated with cell survival and growth. Here, we show that IKKϵ interacts with and phosphorylates estrogen receptor α (ERα) on serine 167 in vitro and in vivo. As a result, IKKϵ induces ERα transactivation a...

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Bibliographic Details
Main Authors: Guo, Jian-Ping, Shu, Shao-Kun, Esposito, Nicole N., Coppola, Domenico, Koomen, John M., Cheng, Jin Q.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823508/
https://ncbi.nlm.nih.gov/pubmed/19940156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078212
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