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IKKϵ Phosphorylation of Estrogen Receptor α Ser-167 and Contribution to Tamoxifen Resistance in Breast Cancer
IKKϵ has recently been identified as a breast cancer oncogene. Elevated levels of IKKϵ are associated with cell survival and growth. Here, we show that IKKϵ interacts with and phosphorylates estrogen receptor α (ERα) on serine 167 in vitro and in vivo. As a result, IKKϵ induces ERα transactivation a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823508/ https://ncbi.nlm.nih.gov/pubmed/19940156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078212 |
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