The Structure of the Mammalian RNase H2 Complex Provides Insight into RNA·DNA Hybrid Processing to Prevent Immune Dysfunction

The mammalian RNase H2 ribonuclease complex has a critical function in nucleic acid metabolism to prevent immune activation with likely roles in processing of RNA primers in Okazaki fragments during DNA replication, in removing ribonucleotides misinserted by DNA polymerases, and in eliminating RNA·D...

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Hauptverfasser: Shaban, Nadine M., Harvey, Scott, Perrino, Fred W., Hollis, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
RNA: Processing and Catalysis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823502/
https://ncbi.nlm.nih.gov/pubmed/19923215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059048
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