Peptide-based Antibodies against Glutathione-binding Domains Suppress Superoxide Production Mediated by Mitochondrial Complex I

Complex I (NQR) is a critical site of superoxide ([Image: see text]) production and the major host of redox protein thiols in mitochondria. In response to oxidative stress, NQR-derived protein thiols at the 51- and 75-kDa subunits are known to be reversibly S-glutathionylated. Although several gluta...

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Main Authors: Chen, Jingfeng, Chen, Chwen-Lih, Rawale, Sharad, Chen, Chun-An, Zweier, Jay L., Kaumaya, Pravin T. P., Chen, Yeong-Renn
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism and Bioenergetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823436/
https://ncbi.nlm.nih.gov/pubmed/19940158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.056846
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