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Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives
ATP-dependent potassium channel openers such as pinacidil and levcromakalim have long been known to shorten action potential duration and to be profibrillatory in non-clinical models, raising concerns on the clinical safety of drugs that shorten QT interval. Routine non-clinical evaluation of new dr...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2010
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823352/ https://ncbi.nlm.nih.gov/pubmed/19563537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00191.x |
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