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Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives

ATP-dependent potassium channel openers such as pinacidil and levcromakalim have long been known to shorten action potential duration and to be profibrillatory in non-clinical models, raising concerns on the clinical safety of drugs that shorten QT interval. Routine non-clinical evaluation of new dr...

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Detalhes bibliográficos
Autor principal: Shah, Rashmi R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823352/
https://ncbi.nlm.nih.gov/pubmed/19563537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00191.x
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