Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

We report an unexpected role for protease signaling in neural tube closure and formation of the central nervous system. Mouse embryos lacking protease-activated receptor 1 and 2 showed defective hindbrain and posterior neuropore closure and developed exencephaly and spina bifida, important human con...

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Detalhes bibliográficos
Main Authors: Camerer, Eric, Barker, Adrian, Duong, Daniel N., Ganesan, Rajkumar, Kataoka, Hiroshi, Cornelissen, Ivo, Darragh, Molly R., Hussain, Arif, Zheng, Yao-Wu, Srinivasan, Yoga, Brown, Christopher, Xu, Shan-Mei, Regard, Jean B., Lin, Chen-Yong, Craik, Charles S., Kirchhofer, Daniel, Coughlin, Shaun R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822780/
https://ncbi.nlm.nih.gov/pubmed/20152175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.11.014
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