Molecular and Functional Characterization of a Novel Cardiac Specific Human Tropomyosin Isoform

BACKGROUND: Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1α (also called α-TM) is the predominant TM isoform in human hearts, the precise TM isoform composition remains unclear. METHODS AND RESULTS: In t...

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Main Authors: Rajan, Sudarsan, Jagatheesan, Ganapathy, Karam, Chehade N., Alves, Marco L., Bodi, Ilona, Schwartz, Arnold, Bulcao, Christian F., D'Souza, Karen M., Akhter, Shahab A., Boivin, Greg P., Dube, Dipak K., Petrashevskaya, Natalia, Herr, Andrew B., Hullin, Roger, Liggett, Stephen B., Wolska, Beata M., Solaro, R. John, Wieczorek, David F.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822663/
https://ncbi.nlm.nih.gov/pubmed/20065163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.889725
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