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Effects of NFκB activation on KSHV latency and lytic reactivation are complex and context-dependent

Like all herpesviruses, Kaposi's sarcoma associated herpesvirus (KSHV) can produce either latent or lytic infection. The latent v-FLIP gene is a strong activator of NF-κB, and in primary effusion lymphoma (PEL) cells, blockade of NF-κB activation is associated with enhanced lytic gene expressio...

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Detalles Bibliográficos
Main Authors: Grossmann, Claudia, Ganem, Don
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822626/
https://ncbi.nlm.nih.gov/pubmed/18321555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.12.044
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