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Mechanisms of chromosomal rearrangement in the human genome

Many human cancers are associated with characteristic chromosomal rearrangements, especially hematopoietic cancers such as leukemias and lymphomas. The first and most critical step in the rearrangement process is the induction of two DNA double-strand breaks (DSB). In all cases, at least one of the...

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Detalhes bibliográficos
Main Authors: Tsai, Albert G, Lieber, Michael R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822523/
https://ncbi.nlm.nih.gov/pubmed/20158866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-S1-S1
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