Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC)

The glutamic acid derivative thalidomide is a transcriptional inhibitor of TNF-α but is also known to affect human blood vessels, which may underlie its teratogenicity. Thalidomide has been used in the treatment of refractory Crohn's disease (CD), but the therapeutic mechanism is not defined. W...

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Bibliographic Details
Main Authors: Rafiee, Parvaneh, Stein, Daniel J., Nelson, Victoria M., Otterson, Mary F., Shaker, Reza, Binion, David G.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
Subjects:
Inflammation/Immunity/Mediators
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822501/
https://ncbi.nlm.nih.gov/pubmed/19926820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00385.2009
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