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Mechanisms of disease pathogenesis in long QT syndrome type 5
KCNE1 associates with the pore-forming α-subunit KCNQ1 to generate the slow (I(Ks)) current in cardiac myocytes. Mutations in either KCNQ1 or KCNE1 can alter the biophysical properties of I(Ks) and mutations in KCNE1 underlie cases of long QT syndrome type 5 (LQT5). We previously investigated a muta...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822495/ https://ncbi.nlm.nih.gov/pubmed/19907016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00308.2009 |
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