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DISPARATE DEVELOPMENTAL NEUROTOXICANTS CONVERGE ON THE CYCLIC AMP SIGNALING CASCADE, REVEALED BY TRANSCRIPTIONAL PROFILES IN VITRO AND IN VIVO

Cell-signaling cascades are convergent targets for developmental neurotoxicity of otherwise unrelated agents. We compared organophosphates (chlorpyrifos, diazinon), an organochlorine (dieldrin) and a metal (Ni(2+)) for their effects on neuronotypic PC12 cells, assessing gene transcription involved i...

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書誌詳細
主要な著者: Adigun, Abayomi A., Seidler, Frederic J., Slotkin, Theodore A.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821997/
https://ncbi.nlm.nih.gov/pubmed/20026089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.12.025
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