DISPARATE DEVELOPMENTAL NEUROTOXICANTS CONVERGE ON THE CYCLIC AMP SIGNALING CASCADE, REVEALED BY TRANSCRIPTIONAL PROFILES IN VITRO AND IN VIVO

Cell-signaling cascades are convergent targets for developmental neurotoxicity of otherwise unrelated agents. We compared organophosphates (chlorpyrifos, diazinon), an organochlorine (dieldrin) and a metal (Ni(2+)) for their effects on neuronotypic PC12 cells, assessing gene transcription involved i...

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Bibliografische gegevens
Hoofdauteurs: Adigun, Abayomi A., Seidler, Frederic J., Slotkin, Theodore A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821997/
https://ncbi.nlm.nih.gov/pubmed/20026089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.12.025
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