Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines

We have engineered recombinant (r) Modified Vaccinia Ankara (MVA) to express multiple antigens under the control of either of two related vaccinia synthetic promoters (pSyn) with early and late transcriptional activity or the modified H5 (mH5) promoter which has predominant early activity. We sequen...

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Détails bibliographiques
Auteurs principaux: Wang, Zhongde, Martinez, Joy, Zhou, Wendi, La Rosa, Corinna, Srivastava, Tumul, Dasgupta, Anindya, Rawal, Ravindra, Li, Zhongqui, Britt, William J., Diamond, Don
Format: Artigo
Langue:Inglês
Publié: Elsevier Ltd. 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821965/
https://ncbi.nlm.nih.gov/pubmed/19969118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.11.056
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