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Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain.

An endogenous membrane-bound substrate of the insulin receptor beta-subunit tyrosine kinase in liver, pp120, has been identified as HA4, a 110-kDa membrane glycoprotein localized primarily to the bile canalicular domain of the hepatocyte. HA4 has been implicated in bile salt transport and cell adhes...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Margolis, R N, Taylor, S I, Seminara, D, Hubbard, A L
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1988
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282164/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2845403/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.19.7256
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