Identification of a Novel “Almost Neutral” Mu Opioid Receptor Antagonist in CHO Cells Expressing the Cloned Human Mu Opioid Receptor

The basal (constitutive) activity of G protein-coupled receptors allows for the measurement of inverse agonist activity. Some competitive antagonists turn into inverse agonists under conditions where receptors are constitutively active. In contrast, neutral antagonists have no inverse agonist activi...

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Hlavní autoři: Sally, Elliott J., Xu, Heng, Dersch, Christina M., Hsin, Ling-Wei, Chang, Li-Te, Prisinzano, Thomas E., Simpson, Denise S., Giuvelis, Denise, Rice, Kenner C., Jacobson, Arthur E., Cheng, Kejun, Bilsky, Edward J., Rothman, Richard B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821452/
https://ncbi.nlm.nih.gov/pubmed/19953652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20723
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