Identification of a Novel “Almost Neutral” Mu Opioid Receptor Antagonist in CHO Cells Expressing the Cloned Human Mu Opioid Receptor

The basal (constitutive) activity of G protein-coupled receptors allows for the measurement of inverse agonist activity. Some competitive antagonists turn into inverse agonists under conditions where receptors are constitutively active. In contrast, neutral antagonists have no inverse agonist activi...

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Main Authors: Sally, Elliott J., Xu, Heng, Dersch, Christina M., Hsin, Ling-Wei, Chang, Li-Te, Prisinzano, Thomas E., Simpson, Denise S., Giuvelis, Denise, Rice, Kenner C., Jacobson, Arthur E., Cheng, Kejun, Bilsky, Edward J., Rothman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821452/
https://ncbi.nlm.nih.gov/pubmed/19953652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20723
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