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Real-time in vivo imaging of p16(Ink4a )gene expression: a new approach to study senescence stress signaling in living animals

Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initiates cellular senescence, the state of irreversible cell cycle arrest, through up-regulatio...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ohtani, Naoko, Yamakoshi, Kimi, Takahashi, Akiko, Hara, Eiji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821322/
https://ncbi.nlm.nih.gov/pubmed/20157424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-5-1
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