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Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease

Purification and in vitro protein-folding schemes were developed to produce monodisperse samples of the mature wild-type HIV-2 protease (PR2), enabling a comprehensive set of biochemical and biophysical studies to assess the dissociation of the dimeric protease. An E37K substitution in PR2 significa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Louis, John M, Ishima, Rieko, Aniana, Annie, Sayer, Jane M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Subscription Services, Inc., A Wiley Company 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821264/
https://ncbi.nlm.nih.gov/pubmed/19798742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.261
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