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Mg(2+)-Assisted Catalysis by B. stearothermophilus TrpRS is Promoted by Allosteric Effects
Mn(2+)-assisted catalysis by B. stearothermophilus TrpRS parallels that in polymerases and reduces specificity in amino acid activation. As predicted by non-equilibrium molecular dynamics simulations, multi-variant thermodynamic cycles with [ATP]-dependent Michaelis-Menten kinetics and Mn(2+) for Mg...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821082/ https://ncbi.nlm.nih.gov/pubmed/19604475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.05.007 |
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