ICP27 Phosphorylation Site Mutants Display Altered Functional Interactions with Cellular Export Factors Aly/REF and TAP/NXF1 but Are Able To Bind Herpes Simplex Virus 1 RNA

Herpes simplex virus 1 (HSV-1) protein ICP27 is a multifunctional regulatory protein that is phosphorylated. Phosphorylation can affect protein localization, protein interactions, and protein function. The major sites of ICP27 that are phosphorylated are serine residues 16 and 18, within a CK2 site...

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Autores principales: Corbin-Lickfett, Kara A., Rojas, Santos, Li, Ling, Cocco, Melanie J., Sandri-Goldin, Rozanne M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820919/
https://ncbi.nlm.nih.gov/pubmed/20015986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01388-09
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