Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms: A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS

Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in the terminal, eighth exon. Proximal splice site selection (PSS) in exon 8 generates pro-angiogenic isoforms such as VEGF(165), and distal splice site selec...

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Autors principals: Nowak, Dawid G., Amin, Elianna Mohamed, Rennel, Emma S., Hoareau-Aveilla, Coralie, Gammons, Melissa, Damodoran, Gopinath, Hagiwara, Masatoshi, Harper, Steven J., Woolard, Jeanette, Ladomery, Michael R., Bates, David O.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820781/
https://ncbi.nlm.nih.gov/pubmed/19906640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074930
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